Respuesta :
Positive selection of thymocytes is necessary to produce a T-cell repertoire capable of interacting with self-MHC molecules. Thus the correct option is A.
What is the purpose of positive selection during T cell development?
To address the necessity that T cells be capable of binding MHC complexes, T cells undergo positive selection. In this process, cells in the thymus present short pieces of proteins known as peptides, on their own MHC class I and class II molecules, allowing immature T cells to bind.
Further the this positive selection process also measures if a T cell will become a CD8+ T cell or a CD4+ T cell. Specifically, if a TCR (T-cell receptor) complex binds strongly to MHC class II, the complex send intracellular signals to induce the expression of a protein called ThPOK. This protein reduces the expression of another key protein, called Runx3, responsible for driving CD8 expression.
For more information regarding MHC complexes, visit:
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