A nonpolar to polar R group substitution changes the structure and function of a protein because polar structure can dissolved polar and non-polar can dissolve non-polar.
The change of nonpolar to polar leads to change in structure and function of protein because the arrangements of atoms are different which leads to change of function as well.
So we can conclude that nonpolar to polar changes the structure and function of a protein because polar structure can dissolved polar and non-polar can dissolve non-polar.
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