Altering or changing the three-dimensional (3D) structure of an enzyme is referred to as: denaturation.
An enzyme can be defined as a biological catalyst that typically speeds up (increases) the rate of a chemical reaction, by lowering (decreasing) the activation energy of its constituent chemical elements (reactants).
In Science, denaturation can be defined as a biological process that involves altering or changing the three-dimensional (3D) structure of an enzyme. Also, it prevents the substrate in a chemical reaction from binding the enzyme's active site.
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