There are different kinds of principles. The general practice of excluding older adults from research, clinical trials in particular, may represent an unintended breach of the principle of IRB Review.
This is known as the body that act to protect the rights and welfare of human subjects by making sure there is equitable subject selection, assuring adequate informed consent, etc.
There are some potential setbacks for individuals who are older in participating in research. This is because old people often have different kinds of symptoms, such as pain, fatigue etc.
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