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How does the supremacy clause of the U. S. Constitution affect the states? It ensures that the U. S. Constitution overrules each state constitution.

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Answer: Article VI, Paragraph 2 of the U.S. Constitution is commonly referred to as the Supremacy Clause. ... It prohibits states from interfering with the federal government's exercise of its constitutional powers, and from assuming any functions that are exclusively entrusted to the federal government.

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