Question

(C) Explain why an increase in glycogen phosphorylase activity might result in an increase in ATP production in the
cell.

d) Researchers claim that, even in the presence of high levels of glucagon and the absence of glycolysis, glucose
6-phosphate cannot be overproduced. Provide reasoning to justify the claim.

Answer 1

Glycogen phosphorylase is required to initiate glycogen degradation. Elevated levels of glucose in blood lead to increased levels of glucose 6-phosphate.

Glycogen phosphorylase and glycolysis

Glycogen phosphorylase is a key enzyme during the initiation of glycogen degradation.

Glycogen degradation is required to produce glucose which enters into the cellular respiration to produce ATP.

Elevated levels of glucose in the blood will lead to increased levels of glucose 6-phosphate, which has a fundamental role in providing glucose during starvation.

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