Question

Hemophilia is an X-linked recessive disorder (Xh) that is passed through generations and can be traced by using a pedigree. Charles is a blank box with a Upper X Upper H Upper Y genotype and Marie is a half-filled circle with a X Upper H x h genotype. What is the probability that a female child of Charles and Marie would suffer from hemophilia? 0 percent 25 percent 50 percent 100 percent.

Answer 1

0% chance HH and Hh are the females genotypes and non of them have the disease

Answer 2

As hemophilia is an X-linked recessive disorder, the likelihood is determined by the X alleles. So, if the father has the dominant allele (H), the likelihood of a female child developing hemophilia (genotype: hh) is 0%, regardless of the mother's genotype. The correct option is A.

What is hemophilia?

Hemophilia is a genetic bleeding disorder in which the blood fails to clot properly. This can result in both spontaneous and post-injury or surgical bleeding.

Blood contains numerous proteins known as clotting factors that can aid in the prevention of bleeding.

As hemophilia is an X-linked recessive disorder, its presence can be determined by the X alleles.

So, if the father has the dominant allele (H), the female child will have 0% chance of having hemophilia, regardless of the mother's genotype.

Thus, the correct option is A.

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