The telomere caps help to maintain genome integrity. In consequence, these repetitive sequences are fundamental to avoid the generation of cancer cells.
Cancer cells are a type of cells that proliferates in an uncontrolled manner, which is generally associated with mutations in the genome capable of altering normal gene expression patterns.
Telomere caps are repeated nucleotide sequences found at the end of chromosomes, which help to maintain genome integrity.
The elimination of these repetitive sequences (telomere caps) due to successive cell divisions triggers chromosomal (genome) instability and thus contributes to the emergence of genomic rearrangements that may lead to carcinogenesis.
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