Cyclins are proteins that regulate the cell cycle. There are specific cyclins per phase. pGoG protein inhibits the expression of cyclins. By blocking the G1 cyclin, pGoG impedes the G1 to S transition in the cell cycle.
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As the cell passes through different steps of cell division, there are auto control mechanisms to ensure that the step was correctly performed and the cell is ready to go to the next step.
Many molecules regulate the cell cycle during the different stages of the mitosis process to make it possible.
There are too many factors interacting, activating, and deactivating to pass from one stage to another.
Cyclins are cell cycle regulator proteins that control the cell during the process of division.
Different types of cycling act on different stages.
When the cell is going through one of the stages, the only cyclin in high levels is the one that is regulating that part of the cycle.
Once that stage is over, that cyclin concentration decreases, and the following one increases.
But if any step was not correctly performed, the cell can not pass to the following one.
pGoG protein ihibits cyclin proteins. So when pGoG protein blocks the expression of the G1 cyclin, the cell can not continue the cell division process.
If the cell does not go through the G1 phase, the cyclins of the S stage are not activated. And if S phase cyclins are not active, the cell can not go to the G2 phase.
The cell remains in the same phase until the DNA replication process is correctly done. And if it does not occur, the cell suffer programmed cell death.
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