A change in the shape of an active site denatures an enzyme by altering the chemical bonds within an enzyme, which decreases the rate of reaction.
An increase in temperature will commonly increase the rate at which an enzyme functions. This will cause the rate of chemical reaction to increase as well. However, for this to occur, the temperature must remain within the optimal range. Anything that exceeds this range will cause the chemical bonds within the enzyme to break and the enzyme to loose it's shape.
When an enzyme is placed in an environment whose temperature exceeds it's optimum range and the enzyme is denaturalized, the active site may lose its shape. When this happens the substrate will not be able to fuse to the enzyme and the chemical reaction which depends on this enzyme will decrease its rate.
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