Positive transcription factor (PTR) is important because it turns genes on to prepare them to be read. What is more important (i.e., which has a greater impact if it is changed): concentration or affinity? If PTR concentration is low but affinity is high, then what will happen to protein levels versus if PTR affinity is high but concentration is low? Argue your point in three to five sentences. Use the simulation if necessary.

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Transcription factors are vital molecules in the control of gene expression, directly controlling when, where and the degree to which genes are expressed. They bind to specific sequences of DNA and control the transcription of DNA into mRNA. Gene regulation is an important part of normal development. Genes are turned on and off in different patterns during development to make a brain cell look and act different from a liver cell or a muscle cell.

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luisvaschetto luisvaschetto · Answer 2 · 2021-12-02T15:57:17+01:00

If PTR concentration is low but affinity is high, then low protein levels will be enough to promote transcription. If PTR concentration is high but affinity is low, then high protein levels will be needed to promote transcription.

A transcription factor is a protein that binds to a specific DNA sequence in order to promote or inhibit transcription.

Transcription factor occupancy refers to the efficiency that exhibits a factor to promote or suppress transcription.

This measurement (occupancy) depends on both the affinity of a particular transcription factor by a specific nucleotide (DNA) sequence and its concentration.

In conclusion, if PTR concentration is low but affinity is high, then low protein levels will be enough to promote transcription. If PTR concentration is high but affinity is low, then high protein levels will be needed to promote transcription.

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