It is false to say that Europe was on the margin of world economy before 1500.
Since ancient times, Europe has traded with the rest of the world as they knew it. They:
- traded with the Mesopotamians during the Phoenician empire era
- traded with the east during the Roman era
- traded with the Middle east during the Muslim age
They even constructed large cities in the 1400s as a result of this trade such as Venice and Genoa.
In conclusion, it is false to say that Europe was on the margin of world economy before 1500 because they traded significantly.
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