RNA's nucleotides are made of a ribose sugar while DNA's are made from a deoxyribose sugar. The difference is that deoxyribose sugar has one less oxygen than a normal ribose sugar.RNA's nucleotides are composed of Uracil an alternate nitrogenous base to Thymine. So the sequence of nitrogenous bases is composed of Adenine, Uracil, Cytosine, and Guanine opposed to Adenine, Thymine, Cytosine, and Guanine.RNA is mainly found in a single stranded form where it loops around itself. DNA on the other hand is a double stranded helix.