Question

Which of the following DNA mutations is likely to have the most negative effect on the protein it specifies?

A.) A codon deletion at the end of a sequence

B.) A base pair deletion, resulting in a different amino acid

C.) A substitution for one serine codon for a different serine codon

D.) A substitution for one stop codon for another stop codon

Answer 1

Answer:

B.) A base pair deletion, resulting in a different amino acid

Explanation:

Answer 2

A base-pair deletion mutation is likely to have the MOST NEGATIVE effect on the protein it specifies (Option B).

• A mutation is any alteration in the nucleotide sequence (DNA) of an organism.

• A base-pair deletion will change the Open reading frame (ORF) of the protein that is synthesized from a given gene sequence, thereby changing all aminoacids downstream the mutation.

• In consequence, a base-pair deletion can significantly alter the protein that will be synthesized from a given gene.

• Moreover, a substitution for a one-stop signal for another stop codon is neutral because it doesn't affect the resulting protein.

In conclusion, a base-pair deletion mutation is likely to have the MOST NEGATIVE effect on the protein it specifies (Option B).

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