Answer:
The significance of the Supreme Court's ability to determine the constitutionality of an act of Congress of a law is that, through Marbury v. Madison, the Supreme Court is the final interpreter of the United States Constitution, in such a way that it becomes the guarantor of its compliance through the judgment of the constitutionality of the laws passed by Congress.
In this way, the Supreme Court controls the legislative action through a check of the constitutionality of the norms, thus giving itself the power to define whether or not a norm will be operative.