Respuesta :
Answer:
Change occur in the genetic makeup.
Explanation:
Brian means that the change occur in the genetic makeup of the mitochondrial DNA that change the structure as well as the function ability of mitochondria which is responsible for the generation of energy for the cell. The mitochondrial DNA are passed from mother to offspring through the egg cell. He signify mitochondrial DNA because the change occur only in the mitochondrial DNA not in the whole organism's DNA.
Brian indicates that the mutation is in a gene found in mitochondrial DNA. What Brian means by this is that mitochondria contain a single circular chromosome that encodes 13 proteins, and that may be due to abnormalities of mitochondrial DNA, to understand better we need.......
Abnormalities in mitochondrial DNA
Each cell has several hundred mitochondria in its cytoplasm. Mitochondria contain a single circular chromosome that encodes 13 proteins, several ribonucleic acids (RNA, ribonucleic acid) and several regulatory enzymes. However, > 90% of mitochondrial proteins are encoded by nuclear genes. For practical purposes, it is assumed that all mitochondria are inherited from the cytoplasm of the egg, so mitochondrial DNA comes only from the mother.
Mitochondrial diseases can result from abnormalities of mitochondrial DNA or nuclear DNA (eg, deletions, duplications, mutations). Tissues with high energy production (eg, muscle, heart, and brain) are at particular risk of dysfunction due to mitochondrial abnormalities. Specific abnormalities in mitochondrial DNA result in characteristic manifestations. Mitochondrial diseases are equally common in men and women.
With this information, we can say that mitochondria have DNA and can undergo mutations, which can cause abnormalities in this DNA.
Learn more about Mitochondria in https://brainly.com/question/10688306
