Well you would use order of operations (PEMDAS).
5×8-(16-4÷2)
Parentheses: (16-4÷2) = (16-2) = 14
5×8-14
There are no exponents.
Multiplication: 5×8=40
40-14
Division was handled within the parentheses.
No addition.
Subtraction: 40-14=26
Answer is 26