The right answer is internal and external environment.
Influence of the internal environment:
In prokaryotes as in eukaryotes, the genes are regulated mainly at the stage of transcription initiation, most often by proteins capable of activating or inhibiting the functioning of the gene. The activators still function by recruitment of RNA polymerase but also, in eukaryotes, protein complexes responsible for the initiation of transcription. This regulation is done according to the needs and the function of the cell.
Influence of the external environment:
Our environment has an influence on our genome by so-called epigenetic modifications. For example, with identical genetic heritages, two twins may evolve differently depending on their respective environments. Individuals, and consequently their genes, are indeed subject to many environmental factors: diet, diseases, drugs and toxins, stress, place & lifestyle, which can modify their cells as much as their DNA.
Answer:
Internal and external environment.
Explanation:
Gene may be defined as the functional segment of the DNA that are inherited from parents to their offspring. Gene is responsible for the genotypic and phenotypic expression of the individual.
The gene regulation can be affected both by the external and internal environment. The inhibtors of the transcription factors may result in decrease gene expression. The expression of a particular gene may increase or decrease during the diseased condition is included in the external environment that affects the gene expression.
Thus, the correct answer is option (4).
