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Which of the following most accurately describes the pathophysiology of sepsis?

A. More than one type of infectious agent invades the body, limiting the immune system's response to each agent.
B. An infectious agent in the body multiplies very rapidly, overwhelming the body's natural immune response.
C. Vasoconstriction and internal fluid retention lead to shock that does not respond to intravenous fluids.
D. The body overreacts to an infection and secretes substances that hurt cells, tissues, and organs.