Many different types of mutations can occur within the body. Cystic fibrosis is a genetic disorder that is caused by different mutations within the CFTR gene. One mutation in the CFTR gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence. Which type of mutation causes this translation error that leads to cystic fibrosis?
silent
missense
nonsense
deletion

A nonsense mutation is one mutation in the CFTR gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence.

Cystic fibrosis is a genetic disorder that is caused by different mutations within the CFTR gene.

The CFTR gene codes for the CFTR protein whose function is as an anion channel (chloride ion) which helps control the movement of water in and out of the membrane of cells that are specialized to produce mucus, sweat, saliva, tears and digestive enzymes

When CFTR protein is defective or absent, thick, sticky mucus accumulates in these cells, obstructing the airways and glands.

The most common mutation of the CFTR gene is a deletion whereby the codon for the amino avid phenylalanine is deleted resulting in the production of a defective CFTR protein.

Another form of mutation in the CFTR gene is a nonsense mutation in which a stop codon is inserted in the middle of the gene resulting in the production of a shortened CFTR protein, which is then degraded by the cell.

Therefore, a nonsense mutation in the CFTR gene leads to cystic fibrosis by causing translation to end earlier in the gene sequence.

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