Nucleoside reverse transcriptase inhibitors (NRTIs) are a class of drugs used to treat human immunodeficiency virus (HIV). Unfortunately, a major side effect of these drugs causes people to get tired very easily, often due to a lack of energy.
Which of the following choices would be the best explanation as to the cause of this drug's side effect?
Choose 1 answer

(Choice A)
A
The drug may be toxic to the endoplasmic reticulum (ER), an organelle that provides a source of energy (ATP) for the cell.

(Choice B)
B
The drug may be toxic to mitochondria, organelles that provide a source of energy (ATP) for the cell.

(Choice C)
C
The drug may be toxic to the Golgi body, an organelle that receives, modifies, and transports cellular materials.

(Choice D)
D
The drug may be toxic to lysosomes, organelles that enzymatically break down cellular wastes.

Nucleoside reverse transcriptase inhibitors (NRTIs) are antiretroviral drugs used against HIV. It has some side effects as it may be toxic to mitochondria that provide cellular energy. Thus, option B is correct.

What are NRTIs?

Nucleoside reverse transcriptase inhibitors (NRTIs) are the drugs used against viral infection that alter the replication mechanism of the antigen as well as the host. This leads to greater side effects from the drug class that targets the structural organization of the antigen.

The NRTIs resemble a thymine base and result in the termination of the replication process and are used in the treatment of human immunodeficiency virus. But the drug causes tiredness after consumption due to a lack of energy.

The symptoms may be caused to the interaction of the drug with the mitochondrial organelle of the cell. As mitochondria are characterized for producing the energy they may get altered by the drug.

Therefore, the NRTIs affect the mitochondria and in turn, decrease energy production.

Learn more about NRTIs here:

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