A sample of an element has a mass of 80.01g and a density of 2.70 g/cm3. How many significant figures does the mass have?

The mass has 4 significant figures
Rules for significant numbers
a sample has mass = 80.01 g
a zero which is located between two non-zero numbers including a significant number, so the mass has 4 significant figures : 8,0,0 and 1