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Answer: The impact was most severe in the Caribbean, where by 1600 Native American populations on most islands had plummeted by more than 99 percent. Across the Americas, populations fell by 50 percent to 95 percent by 1650. The disease component of the Columbian Exchange was decidedly one-sided.

Explanation:

The changea described as most severe in the Caribbean because more than 1600 Native American populations on most islands had plummeted by more than 99 percent.

The arrival of Columbus means when an explorer under the reign of European monarch discovered the New world known as America.

However, the demographic changes that occur as a result of the arrival of Columbus was described as most severe in the Caribbean because more than 1600 Native American populations on most islands had plummeted by more than 99 percent.

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