Question

Which issue is related to long-term heroin use?
pleasure
depression
hypoxia
mood swings

Answer 1

Increased Tolerance

Tolerance means the user requires more and more of the drug to feel the same effects and dependence means withdrawal symptoms will manifest if the user attempts to quit using abruptly.

Dopamine Production

Dopamine is a neurotransmitter that plays a large role in how your brain controls emotion, feelings of pleasure, and movement.2

Heroin triggers dopamine production, along with other neurochemicals. However, the brain reduces production of domaine it and starts relying on heroin use as the primary source of production. A shortage of dopamine is linked to symptoms of Parkinson's disease

Withdrawal Symptoms

When someone abruptly quits using heroin, withdrawal symptoms can begin within a few hours. Usually, the most severe withdrawal symptoms peak between 24 and 48 hours after the last dose and subside after about a week. However, some users experience persistent symptoms for many months

Risks of Addiction

Probably the most common long-term effect of heroin use is an addiction—described by the National Institute on Drug Abuse as "a complex disease, and quitting usually takes more than good intentions or a strong will."5

Heroin addiction causes the user to experience uncontrollable drug-seeking behavior regardless of the consequences. Heroin addiction is so profound that seeking and using the drug can become the primary purpose in the addict's life.

Answer 2

Heroin is a highly addictive opioid and the long-term heroin use is associated with depression.

What is heroin?

Heroin is a psychoactive drug which when taken produces feeling of euphoria.

Heroin is a highly addictive drug.

Prolonged heroin use has been linked to feeling of depression.

Since, heroin numbs pain, its continuous use alters the mood and hormone of the individual and thus lowers the level of serotonin in the body.

Therefore, long-term heroin use is associated with depression.

Learn more about heroin and depression at: https://brainly.com/question/887876