The New England colonies obviously have a much colder climate, and they were highly focused on trade, fishing, and all of that sort. They also believed in religious freedom. They had farm land, but there wasn't a ton like there was in the middle and southern colonies. There were little to no slaves in these colonies.
The Middle colonies kind of have the middle of the deal. They had fertile farm lands, and are also focused on religious freedom. They had a ton of diversity, and were mainly focused on practices such as representative government. Along with this, they had some slaves, but not nearly as much as the southern colonies.
The Southern colonies are the ones that are a bit more strict on beliefs and protocols and whatnot. They had a ton of fertile farmland, and have a ton of slaves that farm it. They also did have religious freedom. The main businesses in this region were farming, literally everything the Southern colonies did was revolving around farming..
In resolution, the colonies were all different and similar in their own ways. Colonial America was a well run system from what I read, it was divided and each particular region flourished. Each region had different strengths and weaknesses, which each colony endured. Therefore, it was beneficial to combine all of those skills later on when the colonies combined to form the United States.