Question

10. Show as many ways as you can think of: a) to make benzamide from benzene; b) to make cyclohexyl methyl ketone from bromocyclohexane;

Answer 1

Answer:

See explanation

Explanation:

a) Benzamide from benzene

For this synthesis, we have to start with the Friedel-Crafts reaction to produce Toluene. Then with a strong oxidant, we can produce benzoic acid. In the next step, we can use an esterification reaction to produce the methyl benzoate. Finally, we can use an acyl substitution reaction using ammonia to produce the benzamide.

b) From bromocyclohexane to cyclohexyl methyl ketone

In this case, we can start with a Grignard reaction. The first step is to produce the Grignard reagent with using magnesium. Then if we add acetaldehyde we can form an alcohol, 1-cyclohexylethan-1-ol. Finally, we can reduce the alcohol to produce cyclohexyl methyl ketone.

See figure 1

I hope it helps!