Question

What is the function of the enzyme topoisomerase in dna replication?

Answer 1

Answer:

Topoisomerase is an enzyme which participates in the unwinding of DNA helix.

Explanation:

During transcription and DNA replication, the DNA needs to be unwound in order for the transcription/replication machinery to gain access to the DNA so it can be copied or replicate, respectively.

Answer 2

The function of the enzyme topoisomerase in dna replication is to change the supercoiling state of DNA.  

The family of topoisomerases is responsible for maintaining the tertiary structure of DNA throughout the life cycle, being responsible for the winding and unwinding of DNA strands.  

About the enzyme topoisomerase:  

• They can repeatedly cut and splice the phosphodiester bonds of the polyphosphodeoxyribose backbone.  

That houses the nitrogenous bases that encode the genetic message.  

• They allow other strands of DNA to pass between the two transiently cleaved strands.  

In carrying out this task, topoisomerases use the energy of the internucleotide bond to covalently bind to the 3' or 5' end of DNA.  

• When DNA strands are spliced, they reverse that covalent bond, reestablishing the initial internucleotide bond.  

In this process, topoisomerase can relieve the torsional stress of the structure in both negative and positive supercoils.  

• If topoisomerases do not work, cells cannot replicate or (un) package DNA or express their genes, so they inexorably die.  

Therefore, we can conclude that topoisomerase is essential in numerous processes, such as replication, since it is necessary to relieve the torsional stress of the DNA molecule for the replication forks or the transcription bubble to progress.  

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