Explain how a change in the amino acid sequence of the FXR1 protein could decrease the ability of the protein to bind to RNA

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17-04-2020
Biology

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Explain how a change in the amino acid sequence of the FXR1 protein could decrease the ability of the protein to bind to RNA

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monica789412 monica789412 · Answer 1 · 2020-04-25T12:54:54+02:00

The amount of proteins which is forming the SDS-resistant aggregates is isolated and purified by using the PSIA-LC-MALDI proteomic approach9 specially made for brain tissues.

Explanation:

It is known as a regulatory mechanism through which the variations in the incorporation of the exons into mRNA gives the production of more output which is to related protein, thus results in expanding possible genomic outputs.

Amyloids are the β-sheets-rich protein fibrils which can cause neurodegenerative and other incurable human diseases trapping millions of humans across the world.

RNA molecules which are colocalized with FXR1 in cortical neurons are insensitive to the treatment with RNase A.
FXR1 also colocalizes in cortical neurons using the amyloid-specific dyes
FXR1 is also known to make different forms of RNA molecules and affects their stability and translation efficiency17.
To determine the binding energy of FXR1 with mRNA, the brain cryosections were hybridized with biotinylated poly-dT.

luisvaschetto luisvaschetto · Answer 2 · 2022-01-24T13:45:34+01:00

A change in the amino acid sequence of the FXR1 protein could decrease the ability of the protein to bind to RNA because this mutation may be associated with a weaker interaction between this protein and RNA.

RFXR1 protein is a well-known RNA-binding protein needed during the embryonic development of the muscle tissues.

Moreover, a mutation is any alteration in the genetic material (DNA) of the genome of an organism.

A mutation may lead to the substitution of a given amino acid in RFXR1, thereby leading to a weaker interaction between this protein and RNA.

In conclusion, a change in the amino acid sequence of the FXR1 protein could decrease the ability of the protein to bind to RNA because this mutation may be associated with a weaker interaction between this protein and RNA.

Learn more about mutations here:

https://brainly.com/question/17106056