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Explanation:

During Mitosis, DNA is replicated during the S phase (Synthesis phase) of Interphase. Interphase is basically the daily life cycle of the cell. Cells spend most of their life in Interphase before Mitosis occurs

Helicase is most likely active in the interphase of the cell cycle.

INTERPHASE OF THE CELL CYCLE:

  • The interphase is the resting phase of the cell cycle. It involves three major stages as follows: G1, Synthesis and G2.

  • The synthesis phase (S) is the stage where the cell replicates its DNA prior to the division of its nucleus.

  • During DNA replication, the double-stranded DNA separates into two single strands via the action of an enzyme called DNA HELICASE.

Therefore, helicase is most likely active in the interphase of the cell cycle.

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