Senator White was against the purchase of Lousiana mainly because of two reasons:
His prediction after the purchase was that they would lose the territory anyways because the Spanish may declare the French ownership invalid or because later the citizens of Lousiana would declare independence from the U.S.A. Obviously, his predications were totally wrong, since the purchase of Louisiana didn't give them just the opportunity to acquire that specific territory, but the position of the U.S became way more stronger since France was not in charge of any territory inside the continent; the Spanish position was very weakened, and finally gave the country access to the western territories that weren't guarded by the Spanish and later by Mexicans. The purchase of Lousiana was a very definitive moment in the growing phase of the United States.