Which of the following statements is not true? Which of the following statements is not true? Compared to whole-genome sequencing, the map-based approach is somewhat cumbersome and time-consuming. Alignment can be difficult in repetitive regions of the genome. Whole-genome sequencing relies on the generation of non-overlapping fragments that are sequenced and aligned to form contigs. Whole-genome sequencing has become the most common method for assembling genomes, with map-based cloning being used to resolve the problems often encountered during whole-genome sequencing.

In complete genome sequencing, a DNA sample is taken from an individual and the identity of each of the three billion nucleotides that make up the human genome is determined.

DNA sequencing means determining the order of the four basic chemical components, called bases, that make up the DNA molecule.

In the DNA double helix, the four chemical bases always unite with the same pair to form base pairs. Adenine (A) is always paired with thymine (T); cytosine (C) is always paired with guanine (G). This pairing is the basis for the mechanism by which DNA molecules are copied when cells divide, and is also the basis for the methods used in most DNA sequencing experiments.