There is a upper limit to chromosome number. The upper limit is caused by incomplete segregation of sister chromatids and trimming of the long arms.
Explanation:
There is a practical limit to the number of chromosomes related to how they can line up in homologous pairs for meiosis in sexually reproducing organisms.
They have a practical limit to number of spindle fibers that you can have in the cell during mitosis.
There is a fern with more than thousand chromosomes. The micronuclei represent loss of DNA from the genome and are lost outright through further cell divisions.
