Question

Which of the following factors would potentially result in a long elimination half-life of a drug?
Group of answer choices

extremely lipophilic

rapid hepatic clearance

significant renal tubular secretion

large elimination rate constant

Answer 1

Factors which would potentially influence the result in a long elimination half-life of a drug are

Rapid hepatic clearance

significant renal tubular secretion

Explanation:

• Factors which would potentially influence the result in a long elimination half-life of a drug are

• Rapid hepatic clearance

• significant renal tubular secretion
• Hepatic drug clearance is a drug that can be defined as the volume of blood perfusing over the liver that is cleared of the drug per unit of time
• intrinsic clearance is the ability of the liver to remove drug during the absence of flow in the limitations and binding to cells or proteins in the blood.
• Tubular secretion is also the transfer of materials from peritubular capillaries to the renal tubular lumen
• Urine is one of the substances leftover in the collecting duct cleared by the reabsorption and secretion.