The p K a of the α‑carboxyl group of serine is 2.21 , and the p K a of its α‑amino group is 9.15 . Calculate the average net charge on serine if it is in a solution that has a pH of 8.80 .

Respuesta :

Explanation:

The given data is as follows.

         pH of serine solution = 8.00

   [tex]pK_{a}[/tex] of carboxylic group of serine = 2.21

  [tex]pK_{a}[/tex] of amino group of serine = 9.15

Therefore, average net charge on serine will be as follows.

        [tex]Q_{serine} = \sum Q^{-} + \sum Q^{+}[/tex]

                   = [tex]\frac{-1}{1 + 10^{-(pH - pK_{a} of carboxylic group}} + \frac{+1}{1 + 10^{pH - pK_{a} of amino group}}[/tex]

                   = [tex]\frac{-1}{1 + 10^{(8.00 - 2.21)}} + \frac{+1}{1 + 10^{(8.00 - 9.15)}}[/tex]

                   = [tex]\frac{-1}{1 + 10^{-5.79}} + \frac{+1}{10^{-11.5}}[/tex]

                   = (-0.999) + (0.934)

                   = 0.0660

Thus, we can conclude that average net charge on serine if it is in a solution that has a pH of 8.80 is 0.0660.