Question

Phosphoinositides mark different cellular membranes and play key roles in protein trafficking inside the cell. Among them, PI(4,5)P2 is involved in receptor-mediated endocytosis as well as phagocytosis at the plasma membrane. This phosphoinositide ...
A. is bound by the adaptor protein AP2.
B. is bound by the GTPase dynamin.
C. is depleted from clathrin-coated vesicles to promote their uncoating.
D. All of the above.

Answer 1

Answer:

All of the above.

Explanation:

PI(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) is the phospholipid present in the minor amount in the plasma membrane. This molecule plays an important role in the cell signaling.

The PI(4,5)P2 is involved in the clathrin coated vesicles and its depletion leads to the uncoating and continues the cell signaling process. The dynamin protein is important for the clathrin coating and and they require the adaptor protein AP2 for the clathrin association.

Thus, the correct answer is option (d).