At the beginning you have 10 balls, 5 of which are red. So, the chance of picking a red ball with the first pick is
[tex]\dfrac{5}{10}=\dfrac{1}{2}[/tex]
When it comes to the second pick, you have 9 balls (because you didn't replace the first red ball), 3 of which are blue. So, you pick a blue ball with the second pick with probability
[tex]\dfrac{3}{9}=\dfrac{1}{3}[/tex]
The two events will occur one after the other with the product of the probabilities:
[tex]\dfrac{1}{2}\cdot\dfrac{1}{3}=\dfrac{1}{6}[/tex]