The Question is not complete . But if I am to be the physician I will increase the strength /dosage of the 3 antihypertensive example:
. If the patient is on this combination Amlodipine (as besylate), valsartan, hydrochlorothiazide; 5mg/160mg/12.5mg , I will increase the dosage gradually to 5mg/160mg/25mg, for the next 2 weeks to see if there is any significant drop in blood pressure, if it remains same , another graduate increase in strength will be done.