There are [tex]\binom{48}6=12,271,512[/tex] ways of drawing 6 numbers between 1 and 48.
Of the 6 drawn numbers, there are [tex]\binom64=15[/tex] ways of drawing 4 matching numbers, and [tex]\binom{42}2=861[/tex] ways of drawing any 2 non-matching numbers.
Hence the probability of winning the prize is
[tex]\dfrac{\binom64\binom{42}2}{\binom{48}6}=\boxed{\dfrac{4,305}{4,090,504}}[/tex]
Note: In case you're unfamiliar with the notation,
[tex]\dbinom nk=\dfrac{n!}{k!(n-k)!}[/tex]