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If it's an internal drive, the BIOS will need to be configured so that the computer "sees" it and gives it an address like D:\

If it's an external USB drive, no BIOS configuration is necessary

Either way, the disk will have to be formatted so that the operating system can read and write to it.
It has to be set up a slave drive, you have to set up the physical jumpers to do it. Connect it to the correct bus and then turn the computer on. After it is recognized by the BIOS and the OS, it is strongly recommended to format it to the file system you use (FAT, NTFS, etc.).