Answer:
Water soluble hormones bind to a cell surface localized receptor initiating a signaling cascade using intracellular second messengers for example epinephrine.
Hormone binding activates the G-protein and G-protein activates the adenylyl cylase and it catalyzed the conversion of ATP to cAMP which is second messenger in this pathway. cAMP activate the protein kinase and then protein kinase activate certain cytoplasmic protein which alter the activity of cell.