When Gregor Mendel conducted his genetic experiments with pea plants, he observed that a trait’s inheritance pattern was the same regardless of whether the trait was inherited from the maternal or paternal parent. Mendel made these observations by carrying out reciprocal crosses: For example, he first crossed a female plant homozygous for yellow seeds with a male plant homozygous for green seeds, and then crossed a female plant homozygous for green seeds with a male plant homozygous for yellow seeds.
Unlike Mendel, however, Morgan obtained very different results when he carried out reciprocal crosses involving eye color in his fruit flies. The diagram below shows Morgan’s reciprocal cross: He first crossed a homozygous red-eyed female with a white-eyed male, and then crossed a homozygous white-eyed female with a red-eyed male.