What are the implications of histone acetylation?
A. Acetyl groups (-COCH3) are attached to positively charged lysines in histone tails.
B. This process seems to loosen chromatin structure.
C. Highly packed heterochromatin has already gone through histone acetylation.
D. It promotes the initiation of transcription.
E. Can cause long-term inactivation of genes in cellular differentiation.