The Monroe Doctrine was largely a response to the problem of
a. the debate over admitting slavers states into the Union
b. the interest of European nations in creating colonies in North and South America
C. fighting between western settlers and Native Americans

Monroe's doctrine was America's policy of opposing European colonialism in America beginning in 1823.
In 1823, US President James Monroe rebelled against the intervention of European countries on the American continent.
The doctrine said that further efforts by European states to seize control of any independent state in North or South America would be seen as "a manifestation of a hostile attitude toward the United States."
At that moment, directed against the interventionist intentions of the Holy Alliance of European Powers towards the former Spanish and Portuguese colonies in South America, that policy later became "America to Americans" and gained a strong national character.

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The Monroe Doctrine was largely a response to the problem ofa. the debate over admitting slavers states into the Unionb. the interest of European nations in creating colonies in North and South AmericaC. fighting between western settlers and Native Americans​