Two neurons always joined axon end to dendrite end. Two neurons are connected through synapses.
Synapses are the points between two neurons that allows them to communicate signals to one another. The signal may be chemical or electrical. The chemical synapse uses chemical messages as a signal to another synapse, while the electrical synapse sends ions as a signal to another synapse.
A single cell can have a varied number of synapses. They are formed when an axon branches out to create communication sites from where a signal is to be sent.