Question

A homeostatic imbalance that activates these bone cells would lead to a loss of bone density. A homeostatic imbalance that activates these bone cells would lead to a loss of bone density.
a) osteoclasts
b) osteoblasts
c) chondroblasts
d) osteocytes

Answer 1

Answer:

The correct answer is A.

Explanation:

An osteoclast is large multinucleated cell present in the bone. Its main function is bone resorption, which occur when the osteoclasts secret hydrogen ions and many enzymes. As a result, bone matrix is digested by them. The most important enzyme is the protease cathepsin K, which degrades collagen.

Cathepsin K is regulated by parathormone, calcitonin and growth factor interleukin 6.

Matrix digestion is key during bone fractures, because it allows the repair and remodeling of the bone. But when this action is excessive, it can lead to osteoporosis (loss of bone density).

Answer 2

A homeostatic imbalance that activates OSTEOCLASTS would lead to a loss of bone density (Option A).

There are two (2) types of specialized cells involved in bone remodeling: osteoblasts or 'bone-forming cells' and osteoclasts, which are bone resorption cells.

Osteoclasts are multinucleated cells involved in bone development and regeneration.

Increased osteoclast activity results in a generalized loss of bone mass and is associated with different bone diseases (e.g., osteoporosis).

In conclusion, a homeostatic imbalance that activates OSTEOCLASTS would lead to a loss of bone density (Option A).

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