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Which of the following statements regarding Nucleotide Excision Repair (NER) and Base Excision Repair (BER) is true? View Available Hint(s) Which of the following statements regarding Nucleotide Excision Repair (NER) and Base Excision Repair (BER) is true? Only NER involves the action of DNA ligase to seal nicks in the DNA backbone. Both NER and BER involve the removal of one or more damaged bases by a nuclease. Both NER and BER can be activated by exposure to visible light. Both NER and BER involve the creation of an apyrimidinic (AP) site.

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DrMantisToboggan

Answer:

Both NER and BER involve the removal of one or more damaged bases by a nuclease

Explanation:

This statement is true b/c in both NER and BER a nuclease will target damaged or distorted regions of DNA.

luisvaschetto

The statement 'both NER and BER involve the removal of one or more damaged bases by a nuclease.' is TRUE.

  • A nuclease is an enzyme capable of cleaving phosphodiester bonds between nucleotides in nucleic acids (either DNA or RNA).

  • Nucleotide excision repair (NER) is a repair pathway that removes large base lesions by incising damaged and replacing DNA strands with DNA synthesized from the undamaged strand.

  • Moreover, base excision repair (BER) is a DNA repair pathway that recognizes and replaces damaged and/or misincorporated nucleotide bases in one DNA strand.

  • BER is distinct from NER in that substrate specificity is largely determined by damage-specific enzymes called DNA glycosylases.

  • In this pathway (BER), specific DNA glycosylases recognize specific damaged DNA regions and then cleave the N-glycosidic bond of the damaged base.

In conclusion, the statement 'both NER and BER involve the removal of one or more damaged bases by a nuclease.' is TRUE.

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