In certain diseases, osteoclast activity takes over osteoblast activity, which will cause the bone to In certain diseases, osteoclast activity takes over osteoblast activity, which will cause the bone to increase the breakdown of the ECM without it being rebuilt, leading to a weakening of the bone. increase in bone matrix to overcome the activity of the osteoclasts. breakdown osteocytes causing the bone to die. have osteocytes convert back to osteoblasts, increasing bone strength.

Osteoclast may be defined as the bone cells that are responsible for the breakdown of bone tissue. Osteoblast is a type of bone cell that are responsible for the formation of bone cells.

The disease in which the osteoclast activity has exceed the osteoblst activity, the bone will start to break at rapid rate. The extracellular matrix (ECM) of the bone will break down but its rebuilt is not possible as the osteoblast cells are performing less role. This cause the breaking and the weakening of the bone of the individual.

Thus, the correct answer is option (1).