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Invaders led by the Spanish conquistador Hernan Cortes overthrew the Aztecs by force and captured Tenochtitlan in 1521, bringing an end to Mesoamerica's last great native civilization.The Spanish campaign began in February 1519, and was declared victorious on August 13, 1521, when a coalition army of Spanish forces and native Tlaxcalan warriors led by Hernán Cortés and Xicotencatl the Younger captured the emperor Cuauhtemoc and Tenochtitlan, the capital of the Aztec Empire.