Answer:
E) the sequence of amino acids in the protein
Explanation:
The sequence of amino acids (aa) in the protein determines the type and order of the aa residues (the variable section of the atom chain).
This residues could be hydrophobic (and they will be located inside the 3-D structure) or hydrophilic (and they will be located outside the 3-D structure). They also could have charges positive (+) or negative (-) and they will interact (+/- sections are atracted and +/+ or -/- are rejected).