Answer:
The correct answer is "by speeding up the rate at which water molecules collide with the substrate".
Explanation:
One of the most common mistakes is to think that enzymes perform the reactions directly, but enzymes act as catalyzers, and the catalysis of hydrolases works by speeding up the rate at which water molecules collide with the substrate. The enzyme lysozyme works under this same premise, and by speeding up the rate of water collision with the substrate, they lower the energy required for its substrate to reach its transition-state conformation. Which ultimately results in the substrate hydrolysis.